The article “John Locke and the New Truth of Empiricism in the Context of Scientific Revolution” aims to study the Idea on empiricism of Locke. The result showed that John Locke was an empirical philosopher who believed that sense was the central tool for the creation of a collection of knowledge. His thoughts were confirmed through the book "An Essay Concerning Human Understanding" which focuses on empirical epistemology knowledge arising during the scientific revolution. This is an important movement of the new knowledge revolution of the 17th century western scholars. The results of the scientific revolution played a critical role in supporting the legitimacy of experiential knowledge-based education, which is what scientists take so far. Meanwhile these streams of thought also passed on to the philosophers of that time.