The purposes of the research were to 1) The development of online computer Instruction with Self-Learning of science and technology course (Computational Science) for Students in Mathayom 2. 2) Find the quality of online computer Instruction with Self-Learning of science and technology course (Computational Science) for Students in Mathayom 2. 3) The development of online computer Instruction with Self-Learning of Science and Technology Course (Computational Science) for Students in Mathayom 2; and 4) Find quality of online computer Instruction with Self-Learning of science and technology course (Computational Science) for Students in Mathayom 2. The target group is professionals who are capable of teaching computers. Information and communication technology, 10 people who used a specific method of choosing. Research instruments 1) online computer instruction 2) lesson plans 3) teaching media quality assessment form.

The research findings showed that the online lessons with self-learning techniques. Science and Technology course (computational science), the results of the evaluation of the quality of online lessons developed Overall, it was at the highest level: Content ( = 4.60, S.D.= 0.45) at the highest level Language ( = 4.57, S.D.= 0.44) at the Advanced Illustration/Media ( = 4.45, S.D.= 0.51) at the highest level Performance and durable ( = 4.58, S.D.= 0.47) at the highest level. 3) Get an online lesson plan in conjunction with self-learning techniques. Science and Technology course (Computational Science) for Mathayomsuksa 2 students; and 4) getting quality online lesson plans combined with self-learning techniques. Science and Technology course (Computational Science) for Grade 2 students. ( = 4.55, S.D.= 0.47)