Water from fish farming contains waste from fish feces, leftover feed and organic substances. It is caused to the spoilage in the water source after water released from fish ponds. The aquaponics system is a combination of fish farming and growing crops by using microorganisms to decompose waste in the water to be nutrients for plants. The aquaponics set consists of 1) a 500 liter fish tank with 400 liters of water placed 0.4 meters above the ground. 2) a 50 liter water tank placed 0.5 meters above the ground. 3) plant plots size 1.0*2.4 meters placed 0.75 meters above the ground 4) water tank 5) water pump and 6) air pump. Air-lift fish farming system for circulating water in the fish tank and flow into the plant field according to gravity. Water was circulated in the system throughout the production period. In this study, the prototype aquaponics system was applied for the sex reverse red tilapia (Oreochromis niloticus x O. mossambicus) combined with tomato cultivation for 8 months. The water quality was in the appropriate criteria. Resulting in the 98±2% survival rate, the average feed conversion rate of 1.12±0.06, tomato yield increased by 10-20% compared to the cultivation in the soil. Also, the experiment was applied with other vegetables such as Chinese cabbage, morning glory, cucumber, etc. The Aquaponics set takes small space, provides a variety of products, reducing the use of antibiotics and chemicals and suitable for household use.