The purpose of this study was to 1) develop multimedia lessons on animation media creation for mathayom suksa two students. 2) compare the learning achievement of students before learning with multimedia lessons via Moodle on cloud, subject to Create animation media for Mathayomsuksa 2 students with normal learning management. The sample group used in this research is 40 mathayom suksa two students in Samutprakarn school were selected by purposive sampling by means of purposive sampling. Used in this study is the development of multimedia lessons with model on cloud on creating animation media for mathayom suksa two students, the achievement test. And the student satisfaction questionnaire The statistics used for data analysis was the t-test Dependent. The results showed that 1) obtained multimedia lessons. Subject: Creating Animation Media for Mathayomsuksa 2 Students with Complete Elements 2, Student Achievement Higher Than Before Learning With significance at .05